Inherited Thrombophilia in a Lebanese Family of Four Generations: A Case Report of Recurrent Miscarriage

Inherited Thrombophilia in a Lebanese Family of Four Generations: A Case Report of Recurrent Miscarriage

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Sara Khalife, Nisrine Bissar-Tadmouri Department of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Tripoli, LebanonCorrespondence: Sara KhalifeDepartment of Medical Laboratory Technology, Faculty of Health Sciences, Beirut Arab University, Tripoli, LebanonTel +961 70 557389Email sara.khalifeh@bau.edu.lbIntroduction: Factor V Leiden (G1691A), prothrombin (G20210A) and MTHFR (C677T) Breast Feeding gene mutations were investigated in many studies for their association with Deep Venous Thrombosis.

Case Presentation: A North Lebanese family has been examined, from an index case, a 40-year-old woman, who had a history of venous thrombosis with unexplained recurrent miscarriage.The index case was found to be heterozygous for factor V Leiden G1691A, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T gene variants.Her family members were heterozygous for at least two of the three-point mutations, and multiple risk factors associated with thrombophilia were identified.Conclusion: Our findings emphasize the need for clarifying the utility and futility of thrombophilia testing in the era of Bosch DIG97IM50B Serie 4 Built In 90cm 3 Speeds B Island Cooker Hood Stainless molecular diagnostics.

Keywords: factor V Leiden G1691A, MTHFR C677T, prothrombin G20210A, deep venous thrombosis, recurrent pregnancy loss, Lebanese family.